Let’s look at Chinese dramas with storylines where a male lead, female lead or a second lead has some disease. You can also recommend some drama I didn’t mention.
Mysterious Lotus Casebook

Chinese Title: 莲花楼 / Lian Hua Lou
Also known As: The Lotus Casebook
Broadcast Network: iQiyi
Broadcast Date: 23 July 2023
Genre: Wuxia, Investigation, Mystery
Ten years ago, Li Xiangyi, the master of Si Gu Sect, dominated with his superior swordsmanship and was a symbol of light in the martial arts world. However, he suddenly disappeared along with Di Feisheng, the leader of the Jin Yuan Alliance, after they arranged to battle in the East Sea.
The Blood of Youth

Chinese Title: 少年歌行 / Shao Nian Ge Xing
Broadcast Website: Youku
Broadcast Date: 26 December 2022
Genre: Historical, Romance, Wuxia
A young man inadvertently ends up in Fallen Snow Villa and becomes involved in a matter that shakes the pugilistic world.
Angels Fall Sometimes

Chinese Title: 谢谢你温暖我 / Xie Xie Ni Wen Nuan Wo
Also known As: 如果还有时间 / Ru Guo Hai You Shi Jian
Broadcast Network: CCTV, Tencent
Broadcast Date: 09 March 2024
Genre: Romance
Lin Tuo and An Zhi Que met at a job fair during the summer internship of their junior year. They fell in love at first sight, and after deepening their understanding of each other, they determined their relationship. Just as love and career were developing in their beautiful direction, Lin Tuo was diagnosed with ALS disease and will die soon.
Love’s Rebellion

Chinese Title: 四海重明 / Si Hai Chong Ming
Also known As: 四海颜歌 / Si Hai Yan Ge
Broadcast Network: iQiyi, Mango TV
Broadcast Date: 31 July 2024 (Mango TV), 01 August 2024 (iQiyi)
Genre: Xianxia, Romance
In order to save her mother, Nan Yan, a “round” girl who is obsessed with farming, stepped into the fairyland, but accidentally planted a “concentric lock” to conclude marriage with Emperor Ji Yang who is hiding his identity by mistake.
The Love You Give Me

Chinese Title: 你给我的喜欢 / Ni Gei Wo De Xi Huan
Broadcast Network: Tencent
Broadcast Date: 24 April 2023
Genre: Romance
Min Hui accidentally met and fell in love with Xin Qi, but they ended up parting ways because of a misunderstanding. Years later, Min Hui and Xin Qi reunited, and fell for each other again. Both sweet and heart-tormenting stories happened between them in life and work.
snowfall

Chinese Title: 冰雪谣 / Bing Xue Yao
Also known As: 如月 / Ru Yue / The Shadow
Broadcast Network: Tencent
Broadcast Date: 29 July 2024
Genre: Republican, Romance, Fantasy
On a fateful night, Shen Zhiheng, a well-known gentleman of high society, crosses paths with Milan, the daughter of a wealthy businessman who has been blind since birth. Milan momentarily regains her sight to break through Shen Zhiheng’s secret to immortality.
Till the End of the Moon

Chinese Title: 长月烬明 / Chang Yue Jin Ming
Broadcast Network: Youku
Broadcast Date: 06 April 2023
Genre: Xianxia, Romance
In an era when the demons are in power, they are the masters of the despicable cultivators and mortals. The cultivator elders deem it necessary to send someone back in time, to determine the origin of the demon lord and to prevent his awakening.
Fangs of Fortune

Chinese Title: 大梦归离 / Da Meng Gui Li
Also known As: 白泽令 / Bai Ze Ling / The Story of Mystics
Broadcast Network: iQiyi
Broadcast Date: 26 October 2024
Genre: Xuanhuan, Romance
The story narrates a magnificent legend where “demons capture demons.” During the Zhenyuan era, due to the accidental death of the Bai Ze goddess, who governed the realms of humans and demons, the Bai Ze Order goes missing, leading to rampant demon beasts causing chaos and numerous bloody murders in the human world.
Unspeakable Longing

Chinese Title: 误入君梦 / Wu Ru Jun Meng
Also Known As: 相思落无声 / Xiang Si Luo Wu Sheng
Broadcast Network: Tencent
Broadcast Date: 29 August 2024
Genre: Historical, Romance
Bai Youke accidentally enters the comic book world she created and becomes the heroine. In order to return to reality, she must make the male protagonist Xu Zeyu who suffers from misogyny fall in love with her. Bai Youke has no choice but to pursue Xu Zeyu, but gradually falls in love with him